B. Pharm 1st year Syllabus

Effect of size of balls, number of balls and time on the efficiency of ball mill. ... Detailed structure of cell membrane & physiology of transport process. .... Knoevenagel reaction, Cannizzaro reaction, Aldol condensation, Benzoin condensation.

Get Price

Solvent-free asymmetric aldol reaction ... - ResearchGate

Nov 3, 2011 ... An efficient, solvent-free ball-milling protocol for the asymmetric aldol reaction between cyclohexanone ... For example, in asymmetric aldol reactions the use ... strated that the efficiency of the process using High Speed Ball-.

Get Price

Sample Chapter - Wiley-VCH

With respect of the many solid/solid reactions known today, it is ... tance given to solvents and the process of dissolution. Although ..... A representative recent example of a highly efficient solvent- free organic synthesis is the (S)-proline-catalysed stereoselective aldol reaction between ... technique such as ball milling [42].

Get Price

Blog | ES Charnwood Molecular Medicinal Chemistry and ...

Some of the reaction conditions are surprisingly mild 25-75 C. ... activity by changing its glycosylation state, inhibiting a process up stream. ... Back in the days of alchemy, a pestle and mortar were employed, today a ball-mill. Anhydride opening, Michael reaction and Aldol reactions are quoted as .... Not very atom efficient.

Get Price

-

2014519 ... ... from chalcones and hydrazine under mechanochemical ball milling. ... Environmentally friendly and efficient process for the preparation of ... Efficient and clean aldol condensation catalyzed by sodium carbonate in water.

Get Price

Ballmilling jackie - SlideShare

Oct 5, 2012 ... Ball Milling An efficient and ecologically friendly synthetic approach ‐‐‐ Jackie Ding. ... Application in Organic Synthesis Aldol Condensations Knoevenagel Condensations Baylis-Hillman Reaction Michael Reaction ... One-pot Tip of Solvent free process iceberg 21; 22.

Get Price

Organocatalysis - RSC Publishing - Royal Society of Chemistry

Apr 19, 2012 ... tutes an efficient bifunctional catalyst in the aldol reaction of cyclic ketones ..... efficiency of the process using High-Speed Ball Milling (Hzenith).

Get Price

Poster Presentations Poster Session 1: PA-001 ~ PA076, RRR-001 ...

“Aldol Condensation of 2-Butanone and Benzaldehyde as a Diagnostic Reaction for Acidic and .... “Highly Efficient Heterogeneous Catalysis by Hollow Mesoporous Aluminosilicate ... Alcohols and on the deactivation process” ... “Decomposition of Cellulose into Water-Soluble Sugars by Dry Ball Milling in the Presence of.

Get Price

Dr Eusebio Juaristi Areas de Investigacion

Rigorous Description of the Inversion Process and Manifestation of .... y E. Juaristi, “Efficient Ball-Mill Procedure in the “Green” Asymmetric Aldol Reaction...

Get Price

A Simple and Green Protocol for 2H-Indazolo[2,1-b]phthalazine ...

Jun 6, 2013 ... ... Annual Issues ·; Article Processing Charges ·; Articles in Press ·; Author Guidelines ... M. Feyzi, “Silica sulfuric acid as an efficient catalyst for the preparation of ... “Organocatalytic reactions: effects of ball milling, microwave and ultrasound ... solvent-free aldol condensation reaction,” Green Chemistry, vol.

Get Price

Reacciones asimétricas organocatalizadas en ausencia de disolvente

28 Ene 2013 ... ABSTRACT (Solvent-free asymmetric organocatalyzed reactions: a strategy towards a greener ..... inter- and intramolecular aldol reaction employing .... Hernández, J. G., Juaristi, E., Efficient ball-mill procedure in the 'green'...

Get Price

Atom efficiency and catalysis in organic synthesis - IUPAC

Atom efficiency and catalysis in organic synthesis .... using facile grinding operation under solvent-free conditions at room temperature. .... Evelina: Solventless Synthesis of N-Protected Amino Acids in a Ball Mill. .... of the origins of the stereoselectivity in the aldol reaction of bicyclic amino ketones in the presence of water.

Get Price

References - Shodhganga

Benign and Highly Efficient Biginelli Reaction. ... milling, microwave and ultrasound irradiation. Green Chem. Vol: 10(11). .... Sonogashira coupling reaction via high speed ball milling. ... Free Mechanochemically Induced Domino Oxa-Michael-Aldol Reaction in a Ball Mill. ..... Simple and practical procedure for Knoevenagel.

Get Price

Water versus Solvent-free Conditions for the Enantioselective ... - RUA

efficient organocatalyst studied promoting the direct aldol reaction of ... reaction times and result in simple and efficient workup procedures. .... efficacy of catalyst 1d was similar when the reaction was performed in a ball mill[9a,9b] (Table 1,.

Get Price

Novel Enantiopure β-Amino Alcohols and β-Amino Thiols in ...

“Solvent-free asymmetric anhydride opening in a ball mill”. Org. Process Res. ..... Enzymes are, on one hand very efficient and selective catalysts, but on the other hand .... An intermolecular aldol reaction was developed by Barbas and List,...

Get Price

Download (671Kb) - White Rose Research Online

May 12, 2015 ... alcohols in solution and in the solid state using ball milling. These optimized procedures are then shown to be applicable to the ... lower temperatures and accelerated reaction time e.g. through ... Aldol reactions8 and Michael .... With an efficient catalyst identi ed and several parameters optimized in...

Get Price

Solvent-Free Asymmetric Organocatalysis in a Ball Mill We are ...

Sep 26, 2006 ... reasonable reaction time, the ball-milling conditions allow the amount of this starting ... a well-studied and efficient CÀC bond-forming reaction, .... General procedure for the proline-catalyzed solvent-free aldol reaction: A...

Get Price

A Highly Efficient Solvent-Free Asymmetric Direct Aldol Reaction ...

Jul 4, 2008 ... stirring after previous dissolution in THF and evaporation, and ball mill technique. These procedures allow one to reduce not only the amount of...

Get Price

A highly efficient asymmetric organocatalytic aldol reaction in a ball ...

Chemistry. 2007;13(17):4710-22. A highly efficient asymmetric organocatalytic aldol reaction in a ball mill. Rodríguez B(1), Bruckmann A, Bolm C.

Get Price

Tulane University - Department of Chemical and Biomolecular ...

Nanostructured Materials; Materials Processing. Nanostructured materials are those ... Reactive High Energy Ball Milling. Functionalized semiconductor...

Get Price

2 Green Chemistry – Aspects for the Knoevenagel Reaction - InTech

Mar 23, 2012 ... carbonyl subunit (9) as an aldol reaction that forms the product (10) of the addition step is ... solvents and auxiliaries; energy efficiency by design; preference for renewable raw ..... ball mill (Wada & Suzuki, 2003). + .... occur through the process of acoustic cavitation, i.e., the formation, growth and implosive.

Get Price

Full-Text PDF - MDPI

Jan 19, 2009 ... as being environmentally friendly, using a simple workup procedure, ... Ball-milling is referred generally to be a mechanical technique ... aldol reaction [21]. ..... A.; Bolm, C. A highly efficient asymmetric organocatalytic Aldol.

Get Price

Mannich-Type Reactions of Aldimines and Hetero Diels-Alder ...

Sep 8, 2012 ... rived from 1b was effective to afford the corresponding β-amino ester in 74% yield .... General Procedure for Mannich-Type Reactions. The catalyst .... tive Direct Aldol Reaction: The Blossoming of Modern .... by (S)-Proline-Containing Thiodipeptides under Ball-. Milling Conditions,” Tetrahedron, Vol. 68, No.

Get Price

Enantioselective direct aldol reaction: the blossoming ... - The Vespiary

compound, the process is called aldol condensation. The ... In order to enhance the global efficiency ..... ball-milling technique facilitated the aldol reaction using.

Get Price

Full text of "Green Organocatalyst Reaction" - Internet Archive

The 12 guidelines essentially fall into four groups: efficient use of energy, hazard ... An example could be offered by a process involving the addition reaction ..... 1.2.1 Asymmetric Cross Aldol Reactions One of the most studied processes is the ... mechanochemical techniques, under solvent-free ball-milling condi- tions.

Get Price

Green Chemistry

term green chemistry has to be applied to a total process, not to an single step. ... with high energy efficiency are recommended to use. Examples are ball milling, microwave irradiation, and ultrasound ..... Aldol condensation. Formation of...

Get Price

PDF(369K) - Wiley Online Library

Nov 6, 2014 ... metric aldol reaction under ball-milling activation in order to establish the influence of a ... similar efficiency in the asymmetric aldol reaction between ... cording to a general procedure described in the literature.[15] In contrast...

Get Price

Efficient ball-mill procedure in the 'green' asymmetric aldol reaction ...

The organocatalytic activity of (S)-proline-based dipeptides 1a–c has been evaluated in the asymmetric aldol reaction between representative ketones with vari.

Get Price

Biobased Chemicals

May 5, 2013 ... Method Of Carbon Chain Extension Using Novel Aldol Reaction. ... Current methods of processing furan materials result in the production of ... Finally, this could be a large-scale, cost effective use of cellulase enzymes which ... work was prepared by ball milling of wood, enzymatic removal of the associated...

Get Price

Mechanochemical organic synthesis.pdf - IUST Personal Webpages

May 9, 2013 ... mills are different and would affect the efficiency of chemical reactions. Therefore, in this review ... A mechanochemical process may involve carbon–carbon ... derived cascade reactions in a ball mill are described. The commonly ...... The aldol reaction as one of the sequential steps in cascade reactions will...

Get Price

a review on current industrial trends for synthesis of medicinal ...

Aug 18, 2013 ... whole cumbersome process initiates with the efforts of synthetic chemistry and ... efficiency and effectiveness of current research efforts. It is important to ..... aldol additions, α-aminations, Michael additions, and Diels–Alder cycloadditions .... Mechanochemistry (Using Ball mill for reactions)- Although solvent.

Get Price

Edition Open Access | Catalysis for the Conversion of Biomass and ...

Although processing cellulose in solution could well hold the key to its efficient ... This results in a rapid rate of hydrolysis at the beginning of the reaction. ..... Moreover, the recycling of ILs is a big challenge due to the lack of efficient ..... on Dilute Acid Hydrolysis of Cellulose by Cellulose Ball-Milling Study Energy and Fuels...

Get Price